Liothyronine 50 mcg tablet is a prescription medication used to treat the symptoms of hypothyroidism (low thyroid hormone), nontoxic goiter (enlarged thyroid gland), myxedema, and myxedema coma. ANALYSIS(16714-166, 16714-167, 16714-168), MANUFACTURE(16714-166, 16714-167, 16714-168), Liothyronine sodium tablets are not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients as there are no clinical benefits and overtreatment with liothyronine sodium may induce hyperthyroidism. It is chemically designated as L-Tyrosine, O - (4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt. Poor compliance or abnormal values may necessitate more frequent monitoring. Closely monitor TSH levels in such patients. Copyright 1996-2022 Cerner Multum, Inc. Monitor patients receiving concomitant liothyronine sodium and sympathomimetic agents for signs and symptoms of coronary insufficiency. Limited published studies report that liothyronine is present in human milk. Liothyronine Sodium 5 microgram Tablets - Summary of Product Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Liothyronine is a man-made form of a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. IndiaMART > Common Disease Medicines > Pharmaceutical Tablets . This dosage may be increased by 5 to 10 mcg daily every 1 or 2 weeks. Sodium Liothyronine Oral: Uses, Side Effects, Interactions, Pictures NDC 16714-167-01 in bottles of 100 tablets with child-resistance closure. This medicine is available only with your doctor's prescription. Use the serum T3 level to monitor adequacy of therapy in this patient population. As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. Thyroid hormones appear to increase catabolism of vitamin K-dependent clotting factors. Levothyroxine and Liothyronine Tablets - Drugs.com Medically reviewed by Drugs.com. In vitro studies indicate that the binding is not easily removed. Do not take two doses at one time. Recommended starting dosage is 25 mcg daily. Home; Search. Carefully monitor glycemic control after starting, changing, or discontinuing liothyronine sodium [see Drug Interactions (7.2)]. Acquired Hypothyroidism in Pediatric Patients. Atrial fibrillation is the most common of the arrhythmias observed with thyroid hormone overtreatment in the elderly. No confirmatory long-term studies in animals have been performed to evaluate carcinogenic potential, mutagenicity, or impairment of fertility in either males or females. Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels. Cytomel is also used to treat or prevent goiter ( enlarged thyroid gland ), and is also given as part of a medical tests for thyroid disorders. The use of thyroid hormones in the therapy of obesity, alone or combined with other drugs, is unjustified and has been shown to be ineffective. Inform patients that the liothyronine in liothyronine sodium tablets is intended to replace a hormone that is normally produced by the thyroid gland. A 50% or greater suppression of uptake indicates a normal thyroid-pituitary axis and thus rules out thyroid gland autonomy. In the elderly or in pediatric patients, therapy should be started with 5 mcg daily and increased only by 5 mcg increments at the recommended intervals. Your doctor will give you a radioactive iodine before and after the 7-day liothyronine. Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given. The dose of liothyronine sodium should target TSH levels within the desired therapeutic range. Selected from data included with permission and copyrighted by First Databank, Inc. 99% Min Muscle Building Weight Loss Steroids Potent Drug Levothyroxine Brand names: Cytomel, Triostat WebMD does not provide medical advice, diagnosis or treatment. Thyroxine is a hormone produced by the thyroid gland in the neck which controls many body functions. 3375 Progress Dr Oxygen may be administered and ventilation maintained. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the liothyronine sodium dose is increased. Take this medication by mouth with or without food as directed by your doctor, usually once daily. These drugs may decrease serum TBG concentration. Liothyronine Sodium T3 is a synthetic hormone that has been used to increase the activity of the thyroid gland. Contact Supplier Request a quote . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Indications and Usage for Levothyroxine and Liothyronine Tablets Levothyroxine and Liothyronine Tablets (thyroid tablets, USP) are indicated: 1. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). Liothyronine is also used in some medical tests to help diagnose problems with the thyroid gland. Phenobarbital increases L-thyroxine metabolism by inducing uridine 5'-diphospho-glucuronosyltransferase (UGT) and leads to a lower T4 serum levels. Essence Pharmaceuticals Private Limited. USP Reference standards 11 USP Levothyroxine RS. Explanation: FDA has concluded that liothyronine sodium is a narrow therapeutic index (NTI) drug based on the following evidence: The range between plasma liothyronine therapeutic and toxic concentrations is narrow In pediatric patients with hypothyroidism, assess the adequacy of replacement therapy by measuring serum TSH and T3 levels. The onset of activity of liothyronine sodium is rapid, occurring within a few hours. Liothyronine Price of 54 Brands / Trade Names | Medindia The biological action of Liothyronine . In patients with primary hypothyroidism, maintain serum TSH in the trimester-specific reference range. Ghaziabad Radhey Sham Vihar, Ghaziabad - 201009, Dist. Liothyronine is given when the thyroid does not produce enough of this hormone on its own. Aidarex Pharmaceuticals LLC. The increased bone resorption may be associated with increased serum levels and urinary excretion of calcium and phosphorous, elevations in bone alkaline phosphatase, and suppressed serum parathyroid hormone levels. Monitor serum T3 levels and maintain in the normal range. Delivery Time: 5 Days. Tell any doctor who treats you that you are using liothyronine. LIOTHYRONINE SODIUM (Generic for CYTOMEL) QTY 90 5 MCG Tablet Near 77381 Add to Medicine Chest Set Price Alert More Ways to Save LIOTHYRONINE/Cytomel (lye oh THYE roe neen) treats low thyroid levels (hypothyroidism) in your body. Do not share this medication with others. Phenobarbital has been shown to reduce the response to thyroxine. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Teva Pharmaceuticals Usa, Inc. NDC Product Code: 0093-2179 Liothyronine Sodium. Should I avoid certain foods while taking Liothyronine SODIUM? Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Commercial (Cytomel): 5 mcg, 25 mcg, 50 mcg Tablet . Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In addition, confusion and disorientation may occur. View liothyronine sodium drug monograph Navigate to section Tablet Capsule Powder for solution for injection There can be variation in the licensing of different medicines containing the same drug. In the US - Call your doctor for medical advice about side effects. Closely monitor infants during the first 2 weeks of thyroid hormone therapy for cardiac overload, arrhythmias, and aspiration from avid suckling. 5 mcg: white to off white, round, flat faced beveled edge, uncoated tablets, debossed with '582' on one side and plain on the other side. Maternal hypothyroidism during pregnancy is associated with a higher rate of complications, including spontaneous abortion, gestational hypertension, pre-eclampsia, stillbirth, and premature delivery. Instruct patients to notify their physician or dentist if they are taking liothyronine sodium tablets prior to any surgery. Pharmaceutical form Tablet. T4 and T3 are produced . The rapid onset and dissipation of action of liothyronine sodium (T3), as compared with levothyroxine sodium (T4), has led some clinicians to prefer its use in patients who might be more susceptible to the untoward effects of thyroid medication. Liothyronine Sodium is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination. Liothyronine Sodium Tablets are a form of thyroxine which is quick acting and long lasting. Liothyronine Sodium (Mayne Pharma): FDA Package Insert, Page 4 In rare instances, allergic skin reactions have been reported with Liothyronine Sodium Tablets, USP. Closely monitor thyroid hormone parameters. PDF Draft Guidance on Liothyronine Sodium February 2022 - Food and Drug Obtain serum TSH, T4, and T3 levels at the end of the trial period, and use laboratory test results and clinical assessments to guide diagnosis and treatment, if warranted [see Dosage and Administration (2.6)]. Concurrent use of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and liothyronine sodium may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines. This medication should not be used for weight loss. Many drugs can exert effects on thyroid hormone pharmacokinetics (e.g. Take this medication regularly to get the most benefit from it. These drugs may cause protein binding site displacement. Hypothyroidism decreases and hyperthyroidism increases the sensitivity to oral anticoagulants. The onset of activity of liothyronine sodium occurs within a few hours. Taking of T3 causes a faster conversion of carbohydrates, proteins, and fats. Treatment may be reinstituted at a lower dosage. However, there is insufficient information to determine the effects of liothyronine on the breastfed infant and no available information on the effects of liothyronine on milk production. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's) and multinodular goiter. Patients receiving insulin or oral hypoglycemics should be closely watched during initiation of thyroid replacement therapy. [CDATA[// >